Article

Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis

2023-01-07

Abstract excerpt

Chronic inflammation and tissue fibrosis are common stress responses that worsen organ function, yet the molecular mechanisms governing their crosstalk are poorly understood. In diseased organs, stress-induced changes in gene expression fuel maladaptive cell state transitions and pathological interaction between diverse cellular compartments. Although chronic fibroblast activation worsens dysfunction of lung, live...

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Literature Corpus work: 84374a3f-adbc-52a2-aae9-9b4ae32751ff
DOI: 10.1101/2023.01.06.522937

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