Bromodomain Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV2 Infection

Abstract excerpt

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined, but could be direct cardiac infection and/or ‘cytokine-storm’ induced dysfunction. To identify mechanisms and discover cardio-protective drugs, we use a state-of-the-art pipeline combining human cardiac organoids with high throughput phosphoproteomics and single nuclei RNA sequencing. We identify t...

Topics

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• Cardiac Fibrosis and Remodeling
• COVID-19 Clinical Research Studies
• Histone Deacetylase Inhibitors Research
• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Renin-Angiotensin System Studies
• SARS-CoV-2 and COVID-19 Research

Identifiers and source

Literature Corpus work

c26376cc-035e-5f1d-93b1-e4e122e1f432

DOI

10.2139/ssrn.3726271