Article

Haematopoietic loss of KDM6A impairs cardiac recovery in heart failure <i>via</i> epigenetic reprogramming of myeloid cells

2025-12-02

Abstract excerpt

Clonal haematopoiesis (CH) is recognized as a potent independent risk factor for cardiovascular disease (CVD). While mutations in common CH-associated genes, such as DNMT3A and TET2 , have been extensively studied, the pathological roles of other CH mutations remain poorly understood. Among these is KDM6A (UTX), an X-linked histone demethylase recently found to be commonly mutated in patients with heart failure....

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Literature Corpus work: 5f9712d5-3a66-54d8-acb0-e6f4deb60ee2
DOI: 10.64898/2025.12.01.691512

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