Article

Dissecting Regulatory Non-Coding GWAS Loci Reveals Fibroblast Causal Genes with Pathophysiological Relevance to Heart Failure

2025-01-22

Abstract excerpt

<title>Abstract</title> <p>Heart failure is caused in part by cardiac remodeling processes that include the death of cardiac myocytes and their replacement by cardiac fibroblasts. We hypothesized that these two cell types may harbor epigenetic contexts in which heart disease-associated non-coding SNPs perturb gene expression relevant to disease. Accordingly, we generated high-resolution Hi-C data layered with fun...

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Literature Corpus work: c9d44042-98f3-5b1b-903f-4bd757ef366c
DOI: 10.21203/rs.3.rs-5837699/v1

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