Article
BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression.
American journal of physiology. Heart and circulatory physiology - 1 Feb 2025
Schuetze Katherine B, Stratton Matthew S, Bagchi Rushita A, Hobby Alexander R H, Felisbino Marina B, Rubino Marcello, Toni Lee S, Reges Caroline, Cavasin Maria A, McMahan Rachel H, Alexanian Michael, Vagnozzi Ronald J, McKinsey Timothy A
Abstract excerpt
Bromodomain and extraterminal domain (BET) proteins, including BRD4, bind acetylated chromatin and coactivate gene transcription. A BET inhibitor, JQ1, prevents and reverses pathological cardiac remodeling in preclinical models of heart failure. However, the underlying cellular mechanisms by which JQ1 improves cardiac structure and function remain poorly defined. Here, we demonstrate that BRD4 knockdown reduced...
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