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Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart Failure

2024-10-13

Abstract excerpt

<h4>Summary</h4> Heart failure is caused in part by cardiac remodeling processes that include the death of cardiac myocytes and their replacement by cardiac fibroblasts. We hypothesized that these two cell types may harbor epigenetic contexts in which heart disease-associated non-coding SNPs perturb gene expression relevant to disease. Accordingly, we generated high-resolution Hi-C data layered with chromatin acc...

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Literature Corpus work: 1d8815b7-e564-5af3-8802-b3b053cc7dec
DOI: 10.1101/2024.10.08.617295

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