Article

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease

2020-07-22

Abstract excerpt

In diseased organs, stress-activated signaling cascades alter chromatin, triggering broad shifts in transcription and cell state that exacerbate pathology. Fibroblast activation is a common stress response that worsens lung, liver, kidney and heart disease, yet its mechanistic basis remains poorly understood 1,2 . Pharmacologic inhibition of the BET family of transcriptional coactivators alleviates cardiac dysfun...

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Literature Corpus work: 331a494e-d96a-54b0-9205-4291e6b90ce3
DOI: 10.1101/2020.07.21.214874

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