Article

Metabolic syndrome in New Zealand Obese mice promotes microglial-vascular interactions and reduces microglial plasticity

2023-10-06

Abstract excerpt

<h4>Summary</h4> Metabolic syndrome (MetS) puts patients more at risk for neurodegenerative diseases such as Alzheimer’s disease (AD). Microglia are implicated as causal factors in AD, however, the effect of MetS on microglia has not been characterized. To address this, we contrasted New Zealand Obese (NZO) with C57BL/6J (B6J) mice in combination with a high fat/high sugar diet (HFD). Irrespective of diet, NZO mi...

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Literature Corpus work: 8434cf71-0754-545c-b639-098e7bf424db
DOI: 10.1101/2023.10.04.560877

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