Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.

doi:10.1186/s13024-020-00415-2

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Article

Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.

Molecular neurodegeneration - 10 Nov 2020

Natunen Teemu, Martiskainen Henna, Marttinen Mikael, Gabbouj Sami, Koivisto Hennariikka, Kemppainen Susanna, Kaipainen Satu, Takalo Mari, Svobodová Helena, Leppänen Luukas, Kemiläinen Benjam, Ryhänen Simo, Kuulasmaa Teemu, Rahunen Eija, Juutinen Sisko, Mäkinen Petra, Miettinen Pasi, Rauramaa Tuomas, Pihlajamäki Jussi, Haapasalo Annakaisa, Leinonen Ville, Tanila Heikki, Hiltunen Mikko

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and T2D share common features, the common molecular mechanisms underlying these two diseases remain elusive. METHODS: Mice with different AD- and/or tauopathy-linked genetic backgrounds (APPswe/PS1dE9, Tau P301L and APPswe/PS1dE9/Tau P301L)...

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PMID: 33168021
DOI: 10.1186/s13024-020-00415-2
PMCID: PMC7653710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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