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Article

Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity

1 Jun 2024

Abstract excerpt

Maternal immune activation is associated with adverse offspring neurodevelopmental outcomes, many mediated by in utero microglial programming. As microglia remain inaccessible throughout development, identification of noninvasive biomarkers reflecting fetal brain microglial programming could permit screening and intervention. We used lineage tracing to demonstrate the shared ontogeny between fetal brain...

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Identifiers

PMID: 38848212
DOI: 10.1016/j.celrep.2024.114326

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