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PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation

2025-10-31

Abstract excerpt

Cerebral small vessel disease (CSVD) is strongly linked to metabolic risk factors and represents a major cause of vascular cognitive impairment and dementia. The interactions of genetic and environmental risk factors driving cerebrovascular pathology in metabolic syndrome are poorly understood. Here, we characterize neuroinflammatory and neurodegenerative phenotypes in a mouse model of metabolic syndrome with athe...

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Literature Corpus work
c4deaa46-ccc4-5de0-a438-9140c472b7b3
DOI
10.1101/2025.10.29.685380
Open publication

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PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and NeuroinflammationDOI 10.1101/2025.10.29.685380
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