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Metabolic stress and age drive inflammation and cognitive decline in mice and humans

1 Mar 2025

Abstract excerpt

INTRODUCTION: Metabolic stressors (obesity, metabolic syndrome, prediabetes, and type 2 diabetes [T2D]) increase the risk of cognitive impairment (CI), including Alzheimer's disease (AD). Immune system dysregulation and inflammation, particularly microglial mediated, may underlie this risk, but mechanisms remain unclear. METHODS: Using a high-fat diet-fed (HFD) model, we assessed longitudinal metabolism and...

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PMID: 40110679
DOI: 10.1002/alz.70060

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