Article

Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity

2023-12-19

Abstract excerpt

<h4>Summary</h4> Maternal immune activation is associated with adverse offspring neurodevelopmental outcomes, many mediated by in utero microglial programming. As microglia remain inaccessible throughout development, identification of noninvasive biomarkers reflecting fetal brain microglial programming could permit screening and intervention. We used lineage tracing to demonstrate the shared ontogeny between feta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b61edc0-9b28-56a5-968b-488f223d5083
DOI: 10.1101/2023.12.16.571680

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesityDOI 10.1101/2023.12.16.571680Read

Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesitySemantic proximity Read

Gene regulatory networks underlying human microglia maturationSemantic proximity Read

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencingSemantic proximity Read

Physiological roles of embryonic microglia and their perturbation by maternal inflammationSemantic proximity Read

Maternal diet disrupts the placenta-brain axis in a sex-specific mannerSemantic proximity Read

Human microglia upregulate cytokine signatures and accelerate maturation of neural networksSemantic proximity Read

Metabolic syndrome in New Zealand Obese mice promotes microglial-vascular interactions and reduces microglial plasticitySemantic proximity Read

The immune landscape of fetal chorionic villous tissue in term placentaSemantic proximity Read

A microglia-containing cerebral organoid model to study early life immune challengesSemantic proximity Read

Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation.Semantic proximity Read

Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory SignalingSemantic proximity Read

At the crux of maternal immune activation: Viruses, microglia, microbes, and <scp>IL‐17A</scp>Semantic proximity Read