Article

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

2021-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in VPS13C cause early onset, autosomal recessive Parkinson’s Disease (PD). We have established that VPS13C encodes a lipid transfer protein localized to contact sites between the endoplasmic reticulum (ER) and late endosomes/lysosomes. In the current study, we demonstrate that depleting VPS13C in HeLa cells causes an accumulation of lysosomes with an altered lipid profile, including an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 842446c0-94ca-542a-9ffb-2b9f3284f911
DOI: 10.1101/2021.06.08.447593

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signalingDOI 10.1101/2021.06.08.447593Read

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling.Semantic proximity Read

Parkinson’s genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomesSemantic proximity Read

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repairSemantic proximity Read

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13CSemantic proximity Read

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repairSemantic proximity Read

VPS13A and VPS13C influence lipid droplet abundanceSemantic proximity Read

Aging-associated endolysosomal decline drives inflammaging and neurodegeneration through the STING-IFN-I axisSemantic proximity Read

Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune responseSemantic proximity Read

ESCRT-dependent STING degradation curtails steady-state and cGAMP-induced signalingSemantic proximity Read

TFEB links the cGAS-STING pathway to lysosome biogenesisSemantic proximity Read

Pathogenic variants in autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activationSemantic proximity Read

VPS35 and the mitochondria: Connecting the dots in Parkinson's disease pathophysiologySemantic proximity Read