Article

Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune response

2022-11-11

Abstract excerpt

<title>Abstract</title> <p>Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy targeting Schwann cells and/or motor neurons. Its multifactorial and polygenic origin portrays a complex clinical phenotype of the disease with a wide range of genetic inheritance patterns. The disease-associated gene <italic>GDAP1</italic> encodes for a mitochondrial outer membrane protein. Mouse and i...

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Literature Corpus work: 067c2368-79bf-563d-bc2f-0c840d03020d
DOI: 10.21203/rs.3.rs-2081745/v1

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