Article

ESCRT-dependent STING degradation curtails steady-state and cGAMP-induced signaling

2022-09-22

Abstract excerpt

STING is an intracellular sensor of cyclic di-nucleotides involved in response to pathogen- or self-derived DNA that induces protective immunity, or if dysregulated, autoimmunity. STING trafficking is tightly linked to its activity. We aimed to systematically characterize genes regulating STING trafficking and to define their impact on STING responses. Based on proximity-ligation proteomics and genetic screens, an...

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Identifiers and source

Literature Corpus work: 490cd07b-9307-59d8-a97a-9be0cf2d86f7
DOI: 10.1101/2022.09.22.509044

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