Article
ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling.
The Journal of cell biology - 4 Jul 2022
Hancock-Cerutti William, Wu Zheng, Xu Peng, Yadavalli Narayana, Leonzino Marianna, Tharkeshwar Arun Kumar, Ferguson Shawn M, Shadel Gerald S, De Camilli Pietro
Abstract excerpt
Mutations in VPS13C cause early-onset, autosomal recessive Parkinson's disease (PD). We have established that VPS13C encodes a lipid transfer protein localized to contact sites between the ER and late endosomes/lysosomes. In the current study, we demonstrate that depleting VPS13C in HeLa cells causes an accumulation of lysosomes with an altered lipid profile, including an accumulation of di-22:6-BMP, a biomarker...
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