Article

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

2024-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in Parkinson’s disease (PD). Here we show that VPS13C, a bridge-like lipid transport protein and a PD gene, is a sensor of lysosome stress/damage. Upon lysosome membrane perturbation, VPS13C rapidly relocates from the cytosol to the surface of lysosomes where it tethers their membranes to the ER. This recruitme...

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Literature Corpus work: a981fc55-074a-5844-bf1d-a64488c7ba35
DOI: 10.1101/2024.06.08.598070

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