Article

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair

2025-10-31

Abstract excerpt

<title>Abstract</title> <p> Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a global early response pathway to lysosome damage. VPS13C readily binds lysosomes under me...

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Identifiers and source

Literature Corpus work: f9bd9702-e732-54c0-9ca4-271bc46eaf4c
DOI: 10.21203/rs.3.rs-7934605/v1

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