Article

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair

2025-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a global early response pathway to lysosome damage. VPS13C readily binds lysosomes under mechanical or...

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Literature Corpus work: f4c90de5-6a02-5b70-b137-2f12910bde9f
DOI: 10.1101/2025.10.23.684214

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