Article

Optimizing Open Source Tools for Protein Design, Characterization, and Docking in Alzheimer's Disease Drug Development

2025-11-12

Abstract excerpt

<p>This study aims to establish a pipeline, or method, for the in-silico discovery of potential protein drugs to treat Alzheimer's Disease (AD). Specifically, this study focuses on the apolipoprotein E (ApoE) protein, the most significant genetic factor in regards to AD development. ApoE has been found to bind to the triggering receptor expressed on myeloid cells 2 (TREM2,) causing the pathogenesis of AD. ApoE has...

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Literature Corpus work: 1e221167-a780-5596-81cd-49cb47277f31
DOI: 10.31222/osf.io/4e9kh_v1

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