Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

2 Mar 2017

Abstract excerpt

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway over-activation can induce detrimental effects. An understanding of the mechanisms mediating Nrf2 inhibition in neurodegenerative conditions may therefore direct the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholinesterase and Neurodegenerative Diseases
Share to Family Support in Illness
Share to Genomics, phytochemicals, and oxidative stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28253260
DOI: 10.1371/journal.pgen.1006593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s diseasePMID 28253260Read ↗

Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2Semantic proximity Read ↗

The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative DiseasesSemantic proximity Read ↗

Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s diseaseSemantic proximity Read ↗

Simultaneous activation of Nrf2 and elevation of antioxidant compounds for reducing oxidative stress and chronic inflammation in human Alzheimer's disease.Semantic proximity Read ↗

The role of Nrf2 signaling pathways in nerve damage repairSemantic proximity Read ↗

An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer’s disease: targeting molecular approach Nrf2, NF-κB, and CREBSemantic proximity Read ↗

NRF2 in neurodegenerative diseasesSemantic proximity Read ↗

Gomisin N rescues cognitive impairment of Alzheimer's disease by targeting GSK3β and activating Nrf2 signaling pathwaySemantic proximity Read ↗

Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?Semantic proximity Read ↗

Targeting Alzheimer's disease hallmarks with the Nrf2 activator IsoeugenolSemantic proximity Read ↗

TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implicationsSemantic proximity Read ↗

Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.