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Article

Nrf2 at the heart of oxidative stress and cardiac protection

29 Nov 2017

Abstract excerpt

The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the expression of antioxidant and detoxification genes. Gene knockout approaches have demonstrated its universal cytoprotective features. While Nrf2 has been the topic of intensive research in cancer biology since its discovery in 1994, understanding the role of Nrf2 in cardiovascular disease has just begun. The literature concerning...

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PMID: 29187515
DOI: 10.1152/physiolgenomics.00041.2017

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