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Article

Bach2 is a potent repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neurons

2019-07-02

Abstract excerpt

Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcriptional activator of antioxidant response elements (ARE), which function to increase expression of antioxidant enzymes. Recent works suggests Nrf2 activation is a promising protective mechanism against the progressive neurodegeneration in Parkinson’s disease (PD). While Nrf2 inducers show some promising results in animal models of PD, the response is...

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Literature Corpus work
0483738c-2d08-5fa3-8a5f-d9e05367e703
DOI
10.1101/687590
Open publication

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Bach2 is a potent repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neuronsDOI 10.1101/687590
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