Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease

4 Nov 2021

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by the loss of nigrostriatal dopaminergic neurons. Mounting evidence suggests that Nrf2 is a promising target for neuroprotective interventions in PD. However, electrophilic chemical properties of the canonical Nrf2-based drugs cause irreversible alkylation of cysteine residues on cellular proteins resulting in side...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibromyalgia and Chronic Fatigue Syndrome Research
Share to IL-33, ST2, and ILC Pathways
Share to Whipple's Disease and Interleukins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34737234
DOI: 10.1073/pnas.2111643118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bach1 derepression is neuroprotective in a mouse model of Parkinson’s diseasePMID 34737234Read ↗

Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s DiseaseSemantic proximity Read ↗

Bach2 is a potent repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neuronsSemantic proximity Read ↗

Nrf2: a modulator of Parkinson’s disease?Semantic proximity Read ↗

FUNCTIONAL ANALYSIS OF BIPARTITE NRF2 ACTIVATORS THAT OVERCOME FEEDBACK REGULATION FOR AGE-RELATED CHRONIC DISEASESSemantic proximity Read ↗

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's DiseaseSemantic proximity Read ↗

Identification of structural features of selected flavonoids responsible for neuroprotection using a <i>Drosophila</i> model of Parkinson’s diseaseSemantic proximity Read ↗

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's diseaseSemantic proximity Read ↗

The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative DiseasesSemantic proximity Read ↗

NRF2 in neurodegenerative diseasesSemantic proximity Read ↗

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's DiseaseSemantic proximity Read ↗

Transcriptome Analysis of a Rotenone Model of Parkinsonism Reveals Complex I-Tied and -Untied Toxicity Mechanisms Common to Neurodegenerative DiseasesSemantic proximity Read ↗

Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related declineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.