Article
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.
Cell host & microbe - 12 Oct 2016
Foster Toshana L, Wilson Harry, Iyer Shilpa S, Coss Karen, Doores Katie, Smith Sarah, Kellam Paul, Finzi Andrés, Borrow Persephone, Hahn Beatrice H, Neil Stuart J D
Abstract excerpt
Interferon-induced transmembrane proteins (IFITMs) restrict the entry of diverse enveloped viruses through incompletely understood mechanisms. While IFITMs are reported to inhibit HIV-1, their in vivo relevance is unclear. We show that IFITM sensitivity of HIV-1 strains is determined by the co-receptor usage of the viral envelope glycoproteins as well as IFITM subcellular localization within the target cell....
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