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Article

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

Nature cell biology - 1 May 2007

Draviam Viji M, Stegmeier Frank, Nalepa Grzegorz, Sowa Mathew E, Chen Jing, Liang Anthony, Hannon Gregory J, Sorger Peter K, Harper J Wade, Elledge Stephen J

Abstract excerpt

Defects in chromosome-microtubule attachment trigger spindle-checkpoint activation and delay mitotic progression. How microtubule attachment is sensed and integrated into the steps of checkpoint-signal amplification is poorly understood. In a functional genomic screen targeting human kinases and phosphatases, we identified a microtubule affinity-regulating kinase kinase, TAO1 (also known as MARKK) as an important...

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PMID: 17417629
DOI: 10.1038/ncb1569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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