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Article

Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2.

Genes & development - 15 May 2016

Schibler Andria, Koutelou Evangelia, Tomida Junya, Wilson-Pham Marenda, Wang Li, Lu Yue, Cabrera Alexa Parra, Chosed Renee J, Li Wenqian, Li Bing, Shi Xiaobing, Wood Richard D, Dent Sharon Y R

Abstract excerpt

Histone H3 methylation on Lys4 (H3K4me) is associated with active gene transcription in all eukaryotes. In Saccharomyces cerevisiae, Set1 is the sole lysine methyltransferase required for mono-, di-, and trimethylation of this site. Although H3K4me3 is linked to gene expression, whether H3K4 methylation regulates other cellular processes, such as mitosis, is less clear. Here we show that both Set1 and H3K4...

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PMID: 27198228
DOI: 10.1101/gad.278887.116
PMCID: PMC4888839

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Source receipt: pubmed, retrieved 7 Sept 2026.

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