Article
Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2.
Genes & development - 15 May 2016
Schibler Andria, Koutelou Evangelia, Tomida Junya, Wilson-Pham Marenda, Wang Li, Lu Yue, Cabrera Alexa Parra, Chosed Renee J, Li Wenqian, Li Bing, Shi Xiaobing, Wood Richard D, Dent Sharon Y R
Abstract excerpt
Histone H3 methylation on Lys4 (H3K4me) is associated with active gene transcription in all eukaryotes. In Saccharomyces cerevisiae, Set1 is the sole lysine methyltransferase required for mono-, di-, and trimethylation of this site. Although H3K4me3 is linked to gene expression, whether H3K4 meth...
Topics
- Benomyl
- Cdc20 Proteins
- Drug Resistance
- Histone-Lysine N-Methyltransferase
- Histones
- Humans
- M Phase Cell Cycle Checkpoints
- Mad2 Proteins
- Methylation
- Mutation
- Protein Binding
- Protein Conformation
- Recombinant Proteins