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Mitotic checkpoint proteins Mad1 and Mad2 - structural and functional relationship with implication in genetic diseases.

Current computer-aided drug design - 1 Jan 2014

Avram Speranta, Mernea Maria, Mihailescu Dan Florin, Seiman Corina Duda, Seiman Daniel Duda, Putz Mihai Viorel

Abstract excerpt

In normal cells, the accuracy of chromosome segregation which assures cells euploidy depends on mitosis mechanics and on proper functioning of a specific complex of proteins represented by the error-checking spindle assembly checkpoint (SAC). SAC proteins are deeply involved in correct cell divisions, but some of these, such as mitotic arrest-deficient proteins (Mad1 and Mad2), are critical. Mad1 and Mad2 are...

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Identifiers

PMID: 24724894
DOI: 10.2174/1573409910666140410124315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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