Article
Stochastically Emergent Tumors offer in vivo whole genome interrogation of cancer evolution from non-malignant precursors
2025-03-18
Abstract excerpt
Interrogating the stochastic events underlying tumor evolution from non-malignant precursors is crucial for understanding therapy resistance. Current methods are complicated by chromosomal instability, obscuring driver identification and yielding non-representative genetics. Inspired by patient tumors that evolve without chromosomal instability, we developed Stochastically Emergent Tumors (SETs) by inducing mismat...
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Identifiers and source
- Literature Corpus work
- 970c3cfa-9a2f-5c17-85ed-1b94a54537cb
- DOI
- 10.1101/2025.03.17.643814