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The many faces of cancer evolution

1 May 2021

Abstract excerpt

Cancer cells acquire genotypic and phenotypic changes over the course of the disease. A minority of these changes enhance cell fitness, allowing a tumor to evolve and overcome environmental constraints and treatment. Cancer evolution is driven by diverse processes governed by different rules, such as discrete and irreversible genetic variants and continuous and reversible plastic reprogramming. In this...

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PMID: 34027317
DOI: 10.1016/j.isci.2021.102403

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