Article

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

2022-04-27

Abstract excerpt

<h4>ABSTRACT</h4> Patients treated with cytotoxic therapies, including autologous stem cell transplantation, are at risk for developing therapy-related myeloid neoplasms 1, 2 . Pre-leukemic clones (i.e., clonal hematopoiesis) are detectable years before the development of these aggressive malignancies 3-5 , though the genomic events leading to transformation and expansion are not well-defined. Here, leveraging...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3210dcec-8613-574c-9293-da351be7b778
DOI: 10.1101/2022.04.26.489507

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid NeoplasmsDOI 10.1101/2022.04.26.489507Read

Tracking the Evolution of Therapy-Related Myeloid Neoplasms Using Chemotherapy SignaturesSemantic proximity Read

The evolution of hematopoietic cells under cancer therapySemantic proximity Read

The evolution of hematopoietic cells under cancer therapy.Semantic proximity Read

Clonal evolution of hematopoietic stem cells after cancer chemotherapySemantic proximity Read

Cancer therapy shapes the fitness landscape of clonal hematopoiesis.Semantic proximity Read

Ontogeny and Natural History of Therapy-Related Clonal Hematopoiesis From a Multidisciplinary CHIP Clinic.Semantic proximity Read

Therapy-Related Myeloid Neoplasm: Biology and Mechanistic Aspects of Malignant ProgressionSemantic proximity Read

Therapy-Related Myeloid Neoplasms: Complex Interactions among Cytotoxic Therapies, Genetic Factors, and Aberrant Microenvironment.Semantic proximity Read

Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolutionSemantic proximity Read

Clonal hematopoiesis-derived therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplant for lymphoid and non-lymphoid disorders.Semantic proximity Read

Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms.Semantic proximity Read

Phylogenetic reconstruction of adult blood cancer reveals early origins and lifelong evolution.Semantic proximity Read