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Article

Inferring mutational timing and reconstructing tumour evolutionary histories.

Biochimica et biophysica acta - 1 Apr 2015

Turajlic Samra, McGranahan Nicholas, Swanton Charles

Abstract excerpt

Cancer evolution can be considered within a Darwinian framework. Both micro and macro-evolutionary theories can be applied to understand tumour progression and treatment failure. Owing to cancers' complexity and heterogeneity the rules of tumour evolution, such as the role of selection, remain incompletely understood. The timing of mutational events during tumour evolution presents diagnostic, prognostic and...

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Identifiers

PMID: 25827356
DOI: 10.1016/j.bbcan.2015.03.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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