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Article

Mapping genomic and epigenomic evolution in cancer ecosystems.

Science (New York, N.Y.) - 24 Sept 2021

Ushijima Toshikazu, Clark Susan J, Tan Patrick

Abstract excerpt

Cancer is a major cause of global mortality underpinned by genomic and epigenomic derangements. Here, we highlight the importance of multimodal data integration in understanding the molecular evolution of malignant cell states across the cancer life cycle. The widespread presence of driver mutations and epigenetic alterations in normal-appearing tissues is prompting a reassessment of how cancer initiation is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34554797
DOI: 10.1126/science.abh1645

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