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Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics.

Nature reviews. Genetics - 1 Jan 2021

Nam Anna S, Chaligne Ronan, Landau Dan A

Abstract excerpt

Cancer represents an evolutionary process through which growing malignant populations genetically diversify, leading to tumour progression, relapse and resistance to therapy. In addition to genetic diversity, the cell-to-cell variation that fuels evolutionary selection also manifests in cellular states, epigenetic profiles, spatial distributions and interactions with the microenvironment. Therefore, the study of...

Topics

Clonal Evolution
Computational Biology
Epigenomics
Genetic Variation
Genomics
Humans
Mutation
Neoplasms
Single-Cell Analysis
Tumor Microenvironment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32807900
DOI: 10.1038/s41576-020-0265-5
PMCID: PMC8450921

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