Article
Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.
Nature - 17 Aug 2017
Joung Julia, Engreitz Jesse M, Konermann Silvana, Abudayyeh Omar O, Verdine Vanessa K, Aguet Francois, Gootenberg Jonathan S, Sanjana Neville E, Wright Jason B, Fulco Charles P, Tseng Yuen-Yi, Yoon Charles H, Boehm Jesse S, Lander Eric S, Zhang Feng
Abstract excerpt
Mammalian genomes contain thousands of loci that transcribe long noncoding RNAs (lncRNAs), some of which are known to carry out critical roles in diverse cellular processes through a variety of mechanisms. Although some lncRNA loci encode RNAs that act non-locally (in trans), there is emerging evidence that many lncRNA loci act locally (in cis) to regulate the expression of nearby genes-for example, through...
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