Evolutionary history of human colitis-associated colorectal cancer.

doi:10.1136/gutjnl-2018-316191

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Article

Evolutionary history of human colitis-associated colorectal cancer.

Gut - 1 Jun 2019

Baker Ann-Marie, Cross William, Curtius Kit, Al Bakir Ibrahim, Choi Chang-Ho Ryan, Davis Hayley Louise, Temko Daniel, Biswas Sujata, Martinez Pierre, Williams Marc J, Lindsay James O, Feakins Roger, Vega Roser, Hayes Stephen J, Tomlinson Ian P M, McDonald Stuart A C, Moorghen Morgan, Silver Andrew, East James E, Wright Nicholas A, Wang Lai Mun, Rodriguez-Justo Manuel, Jansen Marnix, Hart Ailsa L, Leedham Simon J, Graham Trevor A

Abstract excerpt

OBJECTIVE: IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic CRC (S-CRC). Here we have dissected the evolutionary history of CA-CRC using multiregion sequencing. DESIGN: Exome sequencing was performed on fresh-frozen multiple regions of carcinoma, adjacent non-cancerous mucosa and blood from 12 patients with...

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Identifiers

PMID: 29991641
DOI: 10.1136/gutjnl-2018-316191
PMCID: PMC6580738

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