Article
Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia.
Clinical and translational gastroenterology - 1 Jul 2020
Zhan Tianzuo, Belle Sebastian, Valentini Erica, Herrmann Simon, Miersch Thilo, Li Moying, Gaiser Timo, Boutros Michael, Ebert Matthias P, Betge Johannes
Abstract excerpt
INTRODUCTION: Colorectal cancer arises in a multistep process of carcinogenesis from normal mucosa. The earliest precursor might be a morphologically inconspicuous precancerous field, harboring cancer-associated mutations. METHODS: We systematically analyzed genetic alterations in 77 tissue samples from 30 patients with sporadic colorectal neoplasms (18 large adenomas and 12 adenocarcinomas) and matched adjacent...
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