Article

GUIDES: sgRNA design for loss-of-function screens

2017-07-26

Abstract excerpt

GUIDES (Graphical User Interface for DNA Editing Screens) is a web-based tool for the design of custom, large-scale CRISPR libraries for loss-of-function screens in human and mouse. GUIDES combines multi-tissue RNA-sequencing data to target expressed exons, protein annotation to target functional domains, sophisticated on-target and off-target guide RNA scoring and other optimizations to create CRISPR libraries di...

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Literature Corpus work: 8329f3ce-6789-540b-88e4-b55d00d9fb05
DOI: 10.1101/168849

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