Article

Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation

2025-12-27

Abstract excerpt

<h4>SUMMARY</h4> Nuclear Factor I (NFI) misexpressions in humans are associated with severe brain malformations, yet the underlying mechanisms remain poorly understood. Here we show that NFIs regulate the broad lineage progression and lifespan of radial glial progenitors (RGPs), and consequently neocortical development in a dose-dependent manner. Human cerebral organoids carrying patient-mimicking NFI mutations...

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Literature Corpus work: 830ffaf9-d7f3-5b84-94f0-1e3e6b59a77b
DOI: 10.64898/2025.12.27.696675

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