FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration

Abstract excerpt

Abnormal neuronal networks arising from perturbations during early brain development contribute to neurodevelopmental disorders. Mutations and deletions of human Fasciculation and Elongation Protein Zeta 1 ( FEZ1 ) are found in schizophrenia and Jacobsen syndrome patients. However, its roles in human brain development and manifestation of clinical pathological symptoms remain unknown. Here, using human cerebral o...

Topics

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• Cerebral Cortex
• Disease Models, Animal
• Forkhead Transcription Factors
• Mutation
• Nerve Tissue Proteins
• Neurodevelopmental Disorders
• Phenotype
• Rett Syndrome

Identifiers and source

Literature Corpus work

39657d60-feb6-5934-a89f-3a7cd884edeb

DOI

10.1101/2022.07.11.499073