Article

WWOX deficiency impairs neurogenesis and neuronal function in human organoids

2024-12-25

Abstract excerpt

WOREE and SCAR12 syndromes are rare neurodevelopmental disorders caused by WWOX mutations, severely impairing brain development. The pleiotropic nature of WWOX complicates identifying specific mechanisms. Using neural organoids and single-cell transcriptomics, we identified radial glial cells (RGs) as preferentially affected, with disrupted cell cycle dynamics leading to an accumulation of cells in the G2/M and S...

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Literature Corpus work: ee3fd1be-e4a2-5662-b3b1-147aac5dce8d
DOI: 10.1101/2024.12.22.630016

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