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<i>Ptf1a</i> robustly drives the gliogenic switch in the rodent embryonic cortex in a dosage-dependent manner by activating pro-glial gene expression programs

2025-10-15

Abstract excerpt

It is widely believed that the gliogenic switch during rodent embryonic development is governed by the orchestrated crosstalk between a cohort of genes and extracellular cues. Here we report that ectopic expression of the single bHLH factor, pancreas transcription factor 1α (PTF1A), is sufficient to drive radial glial progenitors (RGPs)-regardless of progenitor heterogeneity and developmental stage-to differentiat...

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Identifiers and source

Literature Corpus work
46f26824-ce8b-5479-8576-2f1b14de21f5
DOI
10.1101/2025.10.14.682493
Open publication

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<i>Ptf1a</i> robustly drives the gliogenic switch in the rodent embryonic cortex in a dosage-dependent manner by activating pro-glial gene expression programsDOI 10.1101/2025.10.14.682493
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