Article

Human-specific NOTCH2NL promotes astrogenesis by expanding proliferative glial progenitor states

2025-12-17

Abstract excerpt

The human cerebral cortex contains an unusually large number of glial cells, particularly astrocytes, yet the developmental and genetic mechanisms underlying their expansion remain poorly understood. While human-specific genes have been shown to promote neuronal production during cortical development, whether such genes also regulate gliogenesis has remained unclear. Here, we identify a previously unrecognized rol...

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Literature Corpus work: 24547cf3-9f92-585d-aec2-742862c9561b
DOI: 10.64898/2025.12.16.694764

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