Article

<i>Pten</i> Orchestrates Neurogenic Radial Glia Lineage Progression and Tunes Neocortical Astrocyte Production

2026-05-05

Abstract excerpt

<h4>SUMMARY</h4> The cerebral cortex consists of immense numbers of neuronal and glial cell-types derived from radial glial progenitor (RGP) cells. How RGPs generate appropriate quantities of distinct cortical cell-types to safeguard a brain of correct size, is not well understood. However, genetic aberration in human, including mutations in PTEN , lead to cortical malformation such as macrocephaly, albeit with...

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Literature Corpus work: a9322ff0-eed7-5878-9988-fbfb0499ba34
DOI: 10.64898/2026.05.01.722191

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