Article

KBTBD4-UM171-CoREST1 Axis Prevents Stress-Induced Aging of Human Hematopoietic Stem Cells

2025-05-28

Abstract excerpt

<title>Abstract</title> <p>UM171 is a small molecule degrader of CoREST1 and MYC through KBTBD4 E3 ligase activation. It was initially characterized as a potent hematopoietic stem cell (HSC) self-renewal agonist, with more recent evidence suggesting that it may counter aging-associated declines in HSC function. Here, using both scRNAseq and in vivo functional approaches, we provide evidence that several key featu...

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Literature Corpus work: 830a9be6-59b2-51f0-ba54-8b94f12276c9
DOI: 10.21203/rs.3.rs-6355173/v1

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