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Article

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171

24 Jun 2020

Abstract excerpt

Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood-derived CD34+ cells and promotes in vitro propagation of long-term repopulating HSCs by preventing differentiation. The phenotype and...

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Share to Epigenetics and DNA Methylation
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PMID: 32582923
DOI: 10.1182/blood.2020005827

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