Hematopoiesis under telomere attrition at the single-cell resolution

Abstract excerpt

The molecular mechanisms that drive hematopoietic stem cell functional decline under conditions of telomere shortening are not completely understood. In light of recent advances in single-cell technologies, we sought to redefine the transcriptional and epigenetic landscape of mouse and human hematopoietic stem cells under telomere attrition, as induced by pathogenic germline variants in telomerase complex genes....

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• Share to Cytomegalovirus and herpesvirus research
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