Article

Cancer-associated KBTBD4 mutations induce differentiation defects and confer a unique therapeutic vulnerability

2026-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic regulation governs stem cell fate and perturbations in these mechanisms often lead to tumor development. The CoREST complex, a critical regulator of neural and hematopoietic stem cell differentiation, is recurrently targeted by gain of function mutations in the ubiquitin ligase KBTBD4 in high-risk embryonal brain tumors. However, the tumorigenic potential of these mutations remains un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d075b924-b849-5d7b-b04d-46d29c335a87
DOI: 10.64898/2026.03.12.711277

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cancer-associated KBTBD4 mutations induce differentiation defects and confer a unique therapeutic vulnerabilityDOI 10.64898/2026.03.12.711277Read

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitmentSemantic proximity Read

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.Semantic proximity Read

KBTBD4-UM171-CoREST1 Axis Prevents Stress-Induced Aging of Human Hematopoietic Stem CellsSemantic proximity Read

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutationSemantic proximity Read

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations.Semantic proximity Read

Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancersSemantic proximity Read

Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM 2BSemantic proximity Read

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.Semantic proximity Read

<i>Pgbd5</i> impacts neuronal differentiation and double strand breaks signaling in the developing cortexSemantic proximity Read

Epigenetic regulator KDM5B loss-of-function delays neuronal differentiation of human iPSCsSemantic proximity Read

Enhancer and metabolic rewiring by KMT2C-COMPASS or KMT2D-COMPASS family loss in cancer creates druggable vulnerabilities.Semantic proximity Read

Histone mutations in cancer.Semantic proximity Read