Article

Exploration of HSPC aging mechanism based upon in vitro cell modeling and MDS clinical sampling

2022-09-02

Abstract excerpt

<h4>Background: </h4> The pathogenetic mechanisms of Myelodysplastic Syndromes (MDS) were undefined. Hematopoietic senescence was manifested by association with malignant myeloid blood diseases, aging and immune dysfunction. Hematopoietic stem/progenitor cell (HSPC) aging was the primary determinant of hematopoietic senescence. <h4>Methods: </h4> In current study, we used an in vitro HSPC aging mouse model that re...

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Literature Corpus work: fa015f3d-4164-5562-b014-a3c286727153
DOI: 10.21203/rs.3.rs-2007552/v1

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